He also served as a record producer and composer on two instrumental tracks on Miles Davis albums: “Backyard Ritual” (from Tutu, 1986) and “Cobra” (from Amandla, 1989). He has also worked with a number of notable Brazilian musicians, including singer Milton Nascimento, percussionist Airto Moreira and singer Flora Purim. Sheila E appeared on Duke’s late-1970s solo albums Don’t Let Go and Master of the Game.
Duke had been fairly visible in the R&B world releasing funk-based songs like “Reach for It” and “Dukey Stick”. In 1979 he traveled to Rio de Janeiro, where he recorded A Brazilian Love Affair. He employed singers Flora Purim and Milton Nascimento and percussionist Airto Moreira. The album featured some Latin jazz and jazz-influenced material. From a jazz standpoint, the album’s most noteworthy songs include Nascimento’s “Cravo e Canela,” “Love Reborn,” and “Up from the Sea It Arose and Ate Rio in One Swift Bite.” In addition was “Brazilian Sugar” which was featured on the 2006 video game Dead or Alive Xtreme 2. Meanwhile, Nascimento’s vocal on the ballad “Ao Que Vai Nascer” is an example of Brazilian pop at its most sensuous. This acclaimed album contained a wide variety of genres.
Duke has also worked as musical director at numerous large-scale musical events, including the Nelson Mandela tribute concert at Wembley Stadium, London in 1988. In 1989, he temporarily replaced Marcus Miller as musical director of NBC’s acclaimed late-night music performance program Sunday Night during its first season. Duke was also a judge for the 2nd annual Independent Music Awards to support independent artists’ careers. 
“No Rhyme or No Reason” can be heard during the period of time designated as Quiet Storm.
Duke’s songs have been used by a wide variety of contemporary musicians in a wide array of genres. These include: “I Love You More”, sampled by house music-act Daft Punk for their hit “Digital Love”; “Guilty”, sampled by electronica music artist Mylo in his song “Guilty of Love” on Destroy Rock & Roll.
“For Love”, sampled by underground hip hop artist MF Doom on his track “I Hear Voices”;
“Someday”, sampled by hip hop artist/producer Kanye West for Common in “Break My Heart” on his “Finding Forever” album; “You and Me”, sampled and used by soul/rhythm and blues influenced hip hop-producer 9th Wonder for his collaboration album with Kaze for the track “Spirit Of ’94” on the album Spirit Of ’94: Version 9.0; and “Reach for It”, sampled by Ice Cube in “True to the Game” on his Death Certificate album and Spice 1 in “In My Neighborhood” on his self-titled debut album.
George Duke performed on the title track of Teena Marie’s Congo Square album.
In the summer of 2011, he put together a trio with David Sanborn and Marcus Miller for a tour across the US of more than 20 sold out shows.
By popular vote, Duke was inducted into The SoulMusic Hall Of Fame at SoulMusic.com in December 2012.
His death was announced recently
If tears could build a stairway, And memories a lane, I’d walk right up to Heaven And bring you home again. Farewell Duke